BEGIN:VCALENDAR VERSION:2.0 PRODID:-//Laboratoire des Sciences du Numérique de Nantes - ECPv6.3.2//NONSGML v1.0//EN CALSCALE:GREGORIAN METHOD:PUBLISH X-WR-CALNAME:Laboratoire des Sciences du Numérique de Nantes X-ORIGINAL-URL:https://www.ls2n.fr X-WR-CALDESC:évènements pour Laboratoire des Sciences du Numérique de Nantes REFRESH-INTERVAL;VALUE=DURATION:PT1H X-Robots-Tag:noindex X-PUBLISHED-TTL:PT1H BEGIN:VTIMEZONE TZID:Europe/Paris BEGIN:DAYLIGHT TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST DTSTART:20190331T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET DTSTART:20191027T010000 END:STANDARD END:VTIMEZONE BEGIN:VEVENT DTSTART;TZID=Europe/Paris:20190425T110000 DTEND;TZID=Europe/Paris:20190425T123000 DTSTAMP:20240329T152544 CREATED:20190402T154356Z LAST-MODIFIED:20190402T154439Z UID:12631-1556190000-1556195400@www.ls2n.fr SUMMARY:Séminaire du Pôle SDD - Invité : Dr. Christopher Quince (University of Warwick\, UK) DESCRIPTION:Le pôle SDD recevra Dr Christopher Quince (University of Warwick\, UK) au LS2N jeudi 25 avril à 11hdans l’amphi du bâtiment 34\, sur le site FST (arrêt tram Michelet Science). \nCe dernier donnera un séminaire intitulé : “ Resolving de novo strain variation from metagenomes for high resolution analysis of microbiomes « . \nRésumé : The importance of strain level variation in the human microbiome is well established. Short read metagenomics has the resolution to resolve strains but most current approaches require reference genomes. Methods for de novo resolving strains are still an area of active development. Strains cannot be simply assembled from metagenomes due to the complexity of the assembly graph when multiple closely related genomes are present. This results in fragmented assemblies of potentially millions of contigs. It is possible to cluster or bin contigs into metagenome assembled genomes (MAGs) using composition and co-occurrence across multiple samples. I will introduce our binning algorithm CONCOCT and illustrate its application to both environmental and human-associated microbial communities. However\, the MAGs that result from metagenome binning are still composites of multiple strains. I will also demonstrate how co-occurrence across samples can also be used to resolve sub populations within MAGs\, using our DESMAN (De novo extraction of strains from metagenomes) pipeline. This leads to a higher resolution picture of microbial community changes. \n  \nUn café d’accueil sera offert à partir de 10h30 dans le hall du bâtiment 34. URL:https://www.ls2n.fr/event/seminaire-du-pole-sdd-invite-dr-christopher-quince-university-of-warwick-uk/ LOCATION:UFR Sciences\, 2 rue de la Houssinière\, Nantes\, 44300\, France CATEGORIES:Actualités,Séminaire ATTACH;FMTTYPE=image/jpeg:https://ls2n.fr/wp-content/uploads/sites/13/2019/04/Christopher-Quince.jpeg END:VEVENT END:VCALENDAR